490 research outputs found
Computing Motion Plans for Assembling Particles with Global Control
We investigate motion planning algorithms for the assembly of shapes in the
\emph{tilt model} in which unit-square tiles move in a grid world under the
influence of uniform external forces and self-assemble according to certain
rules. We provide several heuristics and experimental evaluation of their
success rate, solution length, runtime, and memory consumption.Comment: 20 pages, 12 figure
Particle Computation: Complexity, Algorithms, and Logic
We investigate algorithmic control of a large swarm of mobile particles (such
as robots, sensors, or building material) that move in a 2D workspace using a
global input signal (such as gravity or a magnetic field). We show that a maze
of obstacles to the environment can be used to create complex systems. We
provide a wide range of results for a wide range of questions. These can be
subdivided into external algorithmic problems, in which particle configurations
serve as input for computations that are performed elsewhere, and internal
logic problems, in which the particle configurations themselves are used for
carrying out computations. For external algorithms, we give both negative and
positive results. If we are given a set of stationary obstacles, we prove that
it is NP-hard to decide whether a given initial configuration of unit-sized
particles can be transformed into a desired target configuration. Moreover, we
show that finding a control sequence of minimum length is PSPACE-complete. We
also work on the inverse problem, providing constructive algorithms to design
workspaces that efficiently implement arbitrary permutations between different
configurations. For internal logic, we investigate how arbitrary computations
can be implemented. We demonstrate how to encode dual-rail logic to build a
universal logic gate that concurrently evaluates and, nand, nor, and or
operations. Using many of these gates and appropriate interconnects, we can
evaluate any logical expression. However, we establish that simulating the full
range of complex interactions present in arbitrary digital circuits encounters
a fundamental difficulty: a fan-out gate cannot be generated. We resolve this
missing component with the help of 2x1 particles, which can create fan-out
gates that produce multiple copies of the inputs. Using these gates we provide
rules for replicating arbitrary digital circuits.Comment: 27 pages, 19 figures, full version that combines three previous
conference article
Tilt: The Video - Designing Worlds to Control Robot Swarms with Only Global Signals
We present fundamental progress on the computational universality of swarms of micro- or nano-scale robots in complex environments, controlled not by individual navigation, but by a uniform global, external force. More specifically, we consider a 2D grid world, in which all obstacles and robots are unit squares, and for each actuation, robots move maximally until they collide with an obstacle or another robot. The objective is to control robot motion within obstacles, design obstacles in order to achieve desired permutation of robots, and establish controlled interaction that is complex enough to allow arbitrary computations. In this video, we illustrate progress on all these challenges: we demonstrate NP-hardness of parallel navigation, we describe how to construct obstacles that allow arbitrary permutations, and we establish the necessary logic gates for performing arbitrary in-system computations
Forming Planetesimals by Gravitational Instability: II. How Dust Settles to its Marginally Stable State
Dust at the midplane of a circumstellar disk can become gravitationally
unstable and fragment into planetesimals if the local dust-to-gas density ratio
mu is sufficiently high. We simulate how dust settles in passive disks and ask
how high mu can become. We settle the dust using a 1D code and test for
dynamical stability using a 3D shearing box code. This scheme allows us to
explore the behavior of small particles having short but non-zero stopping
times in gas: 0 < t_stop << the orbital period. The streaming instability is
thereby filtered out. Dust settles until shearing instabilities in the edges of
the dust layer threaten to overturn the entire layer. In this state of marginal
stability, mu=2.9 for a disk whose bulk (height-integrated) metallicity is
solar. For a disk whose bulk metallicity is 4x solar, mu reaches 26.4. These
maximum values of mu, which depend on the background radial pressure gradient,
are so large that gravitational instability of small particles is viable in
disks whose bulk metallicities are just a few (<4) times solar. Earlier studies
assumed that dust settles until the Richardson number Ri is spatially constant.
Our simulations are free of this assumption but provide support for it within
the dust layer's edges, with the proviso that Ri increases with bulk
metallicity in the same way that we found in Paper I. Only modest enhancements
in bulk metallicity are needed to spawn planetesimals directly from small
particles.Comment: Accepted to Ap
A Randomized Trial to Identify Accurate and Cost-Effective Fidelity Measurement Methods for Cognitive-Behavioral Therapy: Project FACTS Study Protocol
Background: This randomized trial will compare three methods of assessing fidelity to cognitive-behavioral therapy (CBT) for youth to identify the most accurate and cost-effective method. The three methods include self-report (i.e., therapist completes a self-report measure on the CBT interventions used in session while circumventing some of the typical barriers to self-report), chart-stimulated recall (i.e., therapist reports on the CBT interventions used in session via an interview with a trained rater, and with the chart to assist him/her) and behavioral rehearsal (i.e., therapist demonstrates the CBT interventions used in session via a role-play with a trained rater). Direct observation will be used as the gold-standard comparison for each of the three methods.
Methods/design: This trial will recruit 135 therapists in approximately 12 community agencies in the City of Philadelphia. Therapists will be randomized to one of the three conditions. Each therapist will provide data from three unique sessions, for a total of 405 sessions. All sessions will be audio-recorded and coded using the Therapy Process Observational Coding System for Child Psychotherapy-Revised Strategies scale. This will enable comparison of each measurement approach to direct observation of therapist session behavior to determine which most accurately assesses fidelity. Cost data associated with each method will be gathered. To gather stakeholder perspectives of each measurement method, we will use purposive sampling to recruit 12 therapists from each condition (total of 36 therapists) and 12 supervisors to participate in semi-structured qualitative interviews.
Discussion: Results will provide needed information on how to accurately and cost-effectively measure therapist fidelity to CBT for youth, as well as important information about stakeholder perspectives with regard to each measurement method. Findings will inform fidelity measurement practices in future implementation studies as well as in clinical practice.
Trial registration: NCT02820623, June 3rd, 2016
Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.
We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset. The individual had two copies of the APOE3 Christchurch (R136S) mutation, unusually high brain amyloid levels and limited tau and neurodegenerative measurements. Our findings have implications for the role of APOE in the pathogenesis, treatment and prevention of Alzheimer's disease
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity.
Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). The nucleotide-repeat expansions are translated into dipeptide-repeat (DPR) proteins, which are aggregation prone and may contribute to neurodegeneration. We used the CRISPR-Cas9 system to perform genome-wide gene-knockout screens for suppressors and enhancers of C9ORF72 DPR toxicity in human cells. We validated hits by performing secondary CRISPR-Cas9 screens in primary mouse neurons. We uncovered potent modifiers of DPR toxicity whose gene products function in nucleocytoplasmic transport, the endoplasmic reticulum (ER), proteasome, RNA-processing pathways, and chromatin modification. One modifier, TMX2, modulated the ER-stress signature elicited by C9ORF72 DPRs in neurons and improved survival of human induced motor neurons from patients with C9ORF72 ALS. Together, our results demonstrate the promise of CRISPR-Cas9 screens in defining mechanisms of neurodegenerative diseases
All the way from … authenticity and distance in world music production
World music and the narratives it produces are at the very centre of a formerly transnational production and consumption process. However, the shortened distance between the sites of production and consumption of this good, brought on by migration and greater participation, has created a dilemma for the UK-based artists who perform it: how to maintain authenticity without the added value of ‘distance’. Therefore, the aim of this article is to examine the ways in which musicians and other participants attempt to overcome this problem and in doing so (re)-construct particular aspects of their identity. Rather than being just another critique on authenticity, this article uses distance as an organizing concept in understanding the challenges facing world music production in the UK
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